从玉米中提取的生物表面活性剂对活性原理渗透的影响

Nowadays, one of the most important challenges in thepharmaceutical industry is to find additives for formulationswhich improve the permeation and solubility of drugs. Usually,because of their solubilising and emulsifying properties, it iscommon to use surfactants in ointments and creams.However, some allergies and adverse effects have beenassociated with these kinds of substances. In this sense, thestudy of biosurfactants as an alternative to syntheticsurfactants is playing a more important role. Biosurfactantsare surface-active compounds, composed of biomolecules,with some advantages in comparison with their chemicalcounterparts, such as biodegradability or low toxicity. For thisreason, the aim of this work was to study the effect of abiosurfactant extract, obtained from a corn-milling industrystream, in drug permeation through polydimethylsiloxane(PDMS). This polymer was chosen as a skin mimic, due to itsgood correlation with an in vivo situation in a case wherebythe penetrant lipophilicity was the prime determinant ofcompound permeation. During this study, the permeation offive drugs in the presence of biosurfactant at differentconcentrations were determined, in comparison with a controlwithout the biosurfactant extract.